منابع مشابه
TRPV1 Antagonists as Analgesic Agents
The last decade (2001 2010), declared as the Decade of Pain Control and Research by the United States Congress, brought significantly advances in our understanding of pain biology. Unfortunately, this has not translated into additional effective treatments of chronic pain conditions. Chronic pain is a debilitating and complex clinical state usually associated with diabetic neuropathy, postherpe...
متن کاملTRPA1 as an Analgesic Target
Humans have cultivated chili peppers for over 5,000 years. For more than 1,000 years extracts from these plants have been used medicinally in the treatment of various forms of pain. As a result, pain researchers have had a longstanding interest in the molecular identity of the receptor for capsaicin, the chemical that produces the sensation of heat from “hot” peppers. When the Julius lab publis...
متن کاملAn assessment of buprenorphine as an analgesic.
Buprenorphine has been shown to be an effective analgesic agent. In this trial buprenorphine was found as an effective analgesic agent in most of surgical emergencies; same was true for post operative cases. The duration of analgesia in this study was found to be nearly 8 hours as compared with morphine which was 5-1/2 hours. In another study after operations (Royll and Versichelas, 1976) the d...
متن کاملTopical and peripheral ketamine as an analgesic.
Ketamine, in subanesthetic doses, produces systemic analgesia in chronic pain settings, an action largely attributed to block of N-methyl-D-aspartate receptors in the spinal cord and inhibition of central sensitization processes. N-methyl-D-aspartate receptors also are located peripherally on sensory afferent nerve endings, and this provided the initial impetus for exploring peripheral applicat...
متن کاملKavain analogues as potential analgesic agents.
BACKGROUND Kavalactones are pharmacologically active compounds present in preparations of the root trunk of Piper methysticum Forst, known as kava. This work describes the analgesic activity of some synthesized analogues of synthetic kavain, which is the main component of kava. METHODS The essays were initially performed against the writhing test in mice, and the most promising compound was a...
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ژورنال
عنوان ژورنال: Canadian University Music Review
سال: 2013
ISSN: 2291-2436,0710-0353
DOI: 10.7202/1014310ar